ROSHNI SHETTY

Chennai, India . roshushetty@gmail.com

I am a final year dual degree student at IIT Madras, with B.Tech (Honors) in Biological Engineering (Specialization: Computational Biology) and M.Tech in Biomedical Engineering.

I am fascinated and enjoy learning the approaches to simplify and understand living organisms using engineering principles. I am also intrigued by advancements in medical physics and technology that help patients and healthcare professionals.
I have been fortunate to work in diverse projects and have gained interests in developmental biology, neuroscience, biophotonics, medical imaging, dynamic systems modeling, synthetic biology, vascular biology, engineered cardiomyocytes and electrophysiology.

Apart from academics, I am an ardent sports lover and have been playing badminton, basketball and athletics since school days. I have won several state level badminton tournaments and represented my school at the CBSE Nationals. At IIT Madras, I have regularly been part of the Inter IIT sports event and also won the Best Female Badminton Player thrice. I also enjoy running, swimming, cricket, and squash.

Education

Indian Institute of Technology, Madras

B.Tech- M.Tech, Dual Degree
B.Tech (Honors): Biological Engineering,
Specialization: Computational Biology

M.Tech: Biomedical Engineering

CGPA: 9.29/10

July 2017 - June 2022

Lourdes Central School, Mangalore

Class 12- All India Senior Secondary Certificate Examination, CBSE
PCMB- Physics, Chemistry, Mathematics, Biology

Grade : 94%

Class 10, All India Secondary School Examination, CBSE

CGPA: 10/10

June 2004 - May 2017

Skills

Experimental Skills
  • Laser Speckle Imaging on bacterial cell cultures
  • Biochemistry Lab: Enzyme kinetics, Estimation of carbohydrates, proteins, nucleic acids, SDS-PAGE, Chromatography
  • Microbiology Lab: Preparation of culture media, streaking, inoculation, cell-counting, staining, antibiotic sensitivity assays
  • Genetic-Engineering Lab: Recombinant DNA Technology

Computational Skills
  • Programming Languages: Advanced: MATLAB, Python, Intermediate: C, Front-End Development: HTML, CSS, JavaScript.
  • Speckle Image Processing
  • Proficient with Microsoft Office tools, LINUX OS
  • Well-versed with bioinformatics, structural biology analysis using open-source software and databases, Molecular dynamics and docking software (AutoDock, GROMACS, VMD, PyMol)

Experience

1. Teaching Assistant

Indian Institute of Technology, Madras

Course: Computer Simulations of Biomolecular Systems (BT5420), July-November, 2021
Course Instructor: Dr. Hamsa Priya Mohana Sundaram
Helped students during installation and trouble-shooting of molecular dynamics software. Documented class attendance, evaluated assignments and clarified student queries.


Course: Engineering Mechanics (AM1100), February-March, 2022
Course Instructor: Dr. Sujatha N


Course: Biochemical Thermodynamics (BT2061), Jan-May, 2022
Course Instructor: Dr. Hamsa Priya Mohana Sundaram

July 2021 - Present

2. Student Researcher

Biophotonics lab, IIT Madras

Guide: Dr. Sujatha N, Biophotonics lab, IIT Madras.

Master's Project: Bio-speckle imaging for bacterial growth analysis.
Awarded SAMSUNG Pravartak Fellowship (2021-22) for the project.
Capturing speckle images of E.coli cell cultures while simultaneously recording growth characteristics and correlating speckle parameters with bacterial growth.

April 2021 - present

3. Student Researcher

Cardiac Bioelectric Systems Laboratory
Johns Hopkins Whiting School of Engineering

Guide: Dr. Leslie Tung

Remote project focusing in-silico iPSC-derived cardiomyocyte electrophysiology population models to understand intrinsic properties- excitability and refractoriness and the effects of antiarrhythmic drugs.

June 2021 - present

4. Undergraduate Student Researcher

Computational Systems Biology Lab, IIT Madras

Guide: Dr. Karthik Raman, Centre for Integrative Biology and Systems medicinE (IBSE), Department of Biotechnology, IIT Madras

Project: Metabolic redundancies, minimal reactomes and interactions in gut microbial species.
Computed minimal reactomes for gut-bacteria in the AGORA database and calculated inter-species interactions using the COBRA toolbox.
Analyzed the relationships and evolution of gut-bacteria to their present metabolic status.

June 2020 - June 2021

5. Student Research Intern

Qbiome Research

Project: Bio-process design for lycopene production in Chlamydomonas reinhardtii
Analyzed SBML models using the COBRA toolbox and applied FSEOF, gene deletion techniques to determine optimal reactions producing lycopene.

January - April 2021

6. International Genetically Engineered Machine (iGEM) competition, IIT Madras

2019- Student Leader
• Team Phyte Club- Production of an anti-cancer drug, camptothecin by trying to engineer endophytic fungi, Fusarium solani . (Silver Medal)
• iGEM Human practices- Initiated ‘The Language Project', a multilingual science communication project. Created comics and video content on synthetic biology in Indian languages.

2018- Team Member
• Team ADaPtat1on- expanding the toolbox for Acinetobacter baylyi ADP1 to make it easier to work with the chassis. (Gold Medal)

January 2018 - January 2020

7. Summer Internship

Developmental Biology, Institute for Stem Cell Science and Regenerative Medicine, (inStem), NCBS, Bangalore

Guide: Dr Akash Gulyani, inStem, Bangalore Life Science Cluster (BLiSC)
Project: Evaluation of photo-tactic behaviour in planaria
Cloned planaria genes and learnt RNAi technique. Performed behavioural assays to study planarian phototactic response.
Developed a computational model using MATLAB to track worm movements.

May - July 2019

8. Summer Schools, Workshops, Hackathon Participations


1. 6th Medical Device Innovation Camp, IIT Bombay (2-24 October, 2021)
- Novel Design Team Award

2. Vizathon 2021, Coronavirus Visualization Team, Harvard University
- Wolfram Award (Top 12 Team Projects)

3. NeuroRehack 2021, Christian Medical College, Vellore (28 June - 16 July, 2021)

4. Drug Discovery Hackathon 2020, organised by AICTE, CSIR and supported by Office of Principal Scientific Advisor, Govt. of India, NIC and MyGov.

5. MIT COVID-19 Challenge: India Turning the Tide, August 2020.

6. Biotech poster presentation competition, Biotecnika, 25th September, 2020
- Final Top 30 poster presenters on Synthetic Biology

7. Center for Computational Brain Research (CCBR) winter course, IIT Madras (January-May 2020)

8. 6th Simons-NCBS Monsoon School (15-22 June, 2018)

9. Centre for Innovation (CFI), Cleaning-bot team project, IIT Madras (October 2017)

Projects

1. Medical Device Innovation Camp (eMEDIC)

Organized by: Biomedical Engineering and Technology Innovation Centre (BETIC), IIT Bombay

– Part of team that prototyped an automated version of the tethered OCT capsule for an early and less invasive screening procedure for Barrett’s Esophagus.

October 2021

2. NeuroRehack21

Guide: Prof. Sivakumar Balasubramanian, CMC Vellore

Project: Development of a Kinect camera-based system for tracking an arm skateboard for arm movement training. Presented the team project at the Workshop on Low-Cost Devices for Rehabilitation and Assistance

28 June - 16 July, 2021

3. Drug Discovery Hackathon 2020

Organisd by: AICTE, CSIR, Govt. of India, NIC and MyGov

PS ID: DDT1-01: Developing a regression-based model for screening compounds with 3CLpro inhibitory activity

October 2020

4. Course Project: Molecular Modelling and Drug Design – BT5230

Guide: Prof. Mukesh Doble, Biomaterials Lab, IIT Madras

Project: Computer aided Drug design – identifying lead inhibitors of SARS Cov2 Spike – S2 subunit. Development of pharmacophore model and docking of top molecules and analysing their ADME and toxicity.

July-November, 2020

5. Course Project: Biomedical Signals and Systems – AM5510

Guide: Prof. Babji Srinivasan, Human-in-the-Loop Cyber-Physical Systems Group, IIT Madras

Electrodermal activity (EDA) and history of experimental techniques and analysis. Learnt methods to analyse and filter EDA signals.

July-November, 2020

6. Course Project: Computational Systems Biology – BT5240

Guide: Prof. Karthik Raman, Systems Biology Lab, IIT Madras

Project: Study of an automaton model of the cell cycle coupled with a basic biochemical ODE model. Understand the transition between cell-cycle phases controlled by the concentrations of the major molecules, total cyclin and MPF.

January-May, 2020

7. Course Project: Transport Phenomena in Biological Systems -BT5051

Guide: Prof. G. K. Suraishkumar, IIT Madras

Project: Estimation of initial velocity, angle of launch and range of a shuttlecock for a ‘toss’ badminton stroke, and the effect of the air drag on the shuttle.

July-November, 2019

Academic Courses

  • Biomedical Imaging Systems (AM5160)
  • Biomedical Sensors and Measurements (AM5050)
  • Biomechanics (AM5010)
  • Physiology for Engineers (AM5119)
  • Biomedical Signals and Systems (AM5510)
  • Biomedical Instrumentation (AM5140)
  • Medical Materials (MM5041)
  • Physiological measurements & instrumentation laboratory (AM5023)
  • Advanced BME Lab (AM5019)

  • Computational Systems Biology (BT5240)
  • Machine Intelligence and Brain Research (ID7123)
  • Protein Interactions: Computational Techniques (BT6320)
  • Molecular Modeling and Drug Design (BT5230)
  • Vascular Biology(BT6230)
  • Principles of Neuroscience(BT5270)
  • Transport Phenomena in Biological Systems(BT5051)
  • Introduction to Developmental Biology(BT5390)
  • Undergraduate Research in Computational Biology (BT4813)
  • Computational Biology Laboratory (BT4110)
  • Current Topics in Synthetic Biology (BT4310)
  • Structural Biology (BT3020)
  • Data Structures and Algorithms for Biology (BT3051)
  • Bioinformatics (BT3040)
  • Analysis and Interpretation of Biological Data (BT3041)
  • Molecular Biology (BT3012)
  • Evolutionary Biology (BT3032)
  • Immunology (BT3072)
  • Biostatistics (BT2022)
  • Numerical methods for biology (BT2020)
  • Genetic Engineering Laboratory (BT2121)
  • Biological Rate Processes (BT2041)
  • Biochemical Thermodynamics (BT2061)
  • Cell Biology (BT2082)
  • Introduction to Biological Physics (PH2070)
  • Microbiology (BT2010)
  • Genetics (BT2012)
  • Biochemistry (BT2030)
  • Microbiology and Biochemistry Lab (BT2111)
  • Differential Equations (MA2020)
  • Material and Energy Balances (BT1020)
  • Signals and Systems (EE1101)
  • Series and Matrices (MA1102)
  • Engineering Mechanics (AM1100)
  • Introduction to Programming (CS1100)
  • Introduction to Biological Sciences & Engineering (BT1000)

  • Machine Learning (Stanford University)
  • Web Design for Everybody: Basics of Web Development & Coding (University of Michigan)
  • Systems Biology and Biotechnology Specialization (ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI)
  • Machine Learning Specialization (University of Washington)
  • Python Programming: A Concise Introduction (Wesleyan University)
  • Introduction to Programming with MATLAB (Vanderbilt University)
  • The Science of Stem Cells (American Museum of Natural History)
  • Demystifying the brain- Prof. V Srinivasa Chakravarthy. (IIT Madras)

    • Made using Template: StartBootstrap-Resume